About us

Groupleader

Prof. Dr. Andreas Thiel

Berlin-Brandenburg Center for Regenerative Therapies (BCRT)
Charité - Universitätsmedizin Berlin
Campus Virchow-Klinikum
Augustenburger Platz 1 (Südstraße 2)
13353 Berlin


Phone: +49 30 450 539 555
Fax: +49 30 450 539 955
andreas.thiel[at]charite.de

 

Academic education

1991-1992         Diploma thesis with Priv. Doz. Dr. Claudia Berek at the Institute for

                          Genetics of the der University of Cologne

                          Thesis title: „Investigation about the HSA-Expression on B-cells

1998                  Graduation at the Faculty of Mathematics and Science of the University

                          of Cologne (PhD)

                          Title: “Isolation and functional characterization of the peripheral stem

                          cells and precursor cells of the haemopoietic system”

1998-2009         Group Leader “Clinical Immunology” DRFZ- Deutsches Rheuma

                          Forschungszentrum Berlin

Since 2009        Group Leader “Immune Regeneration and Aging” at the BCRT-Charité

10/2009             Professorship for Regenerative Immunology and Aging at the at the

                          Charité-Universitätsmedizin Berlin

 

Positions and Honors

1998 -2008       Group Leader „Clinical Immunology“ at the Deutsches Rheuma-

                         Forschungszentrum Berlin

11/2007            Leader of the cytometric Core-Facility at the Deutsches Rheuma-

                         Forschungszentrum Berlin, a joined institution by the Charité,

                         the Max-Planck-Institute für Infection Biology and the Deutsches

                         Rheuma-Forschungszentrum Berlin

2008                 Principial investigator at the Berlin-Brandenburg Center for Regenerative

                         Therapien (BCRT), Charité Universitätsmedizin Berlin

6/2008              Primo Loco Position for a W2 Professorship „Regenerative Immunology

                         and Aging“ at the Berlin-Brandenburg Center for Regenerative Therapies

                        (BCRT), Charité Universitätsmedizin Berlin

2/2009              Movement to the Berlin-Brandenburg Center for Regenerative Therapies

                         (BCRT), Charité Universitätsmedizin Berlin

10/2009            W2 Professor `Regenerative Immunology and Aging´ am

                         Berlin-Brandenburg Center für Regenerative Therapien (BCRT),

                         Charité Universitäts Medizin Berlin

 

Recent publications

Frentsch M, Arbach O, Kirchhoff D, Moewes B, Worm M, Rothe M, Scheffold A, Thiel A. 2005. Direct access to CD4+ T cells specific for defined antigens according to CD154 expression. Nature Med. 11(10):1118-1124.

 

Alexander T*, Thiel A*, Rosen O, Massenkeil G, Sattler A, Kohler S, Mei H, Radtke H, Gromnica-Ihle E, Burmester GR, Arnold R, Radbruch A, Hiepe F. 2009. Depletion of autoreactive immunologic memory followed by autologous hematopoietic stem cell transplantation in patients with refractory SLE induces long-term remission through de novo generation of a juvenile and tolerant immune system. *equal contribution. Blood. 113(1): 214-23.

 

Kohler S, Thiel A. 2009. Life after the thymus: CD31+ and CD31- human naive CD4+ T-cell subsets. Blood. 113(4): 769-74.

 

Sattler A, Wagner U, Rossol M, Sieper J, Wu P, Krause A, Schmidt WA, Radmer S, Kohler S, Romagnani C, Thiel A. 2009.        Cytokine-induced human IFN-gamma-secreting effector-memory Th cells in chronic autoimmune inflammation. Blood. 113(9): 1948-56.

Senior Scientist

Dr. Marco Frentsch

Contact:

Phone: +49 (0)30 - 450 539 489
marco.frentsch[at]charite.de

Academic education

  • 1995-1996: studies Chemistry at the Freie Universität Berlin
  • 1996-2002: studies Biochemistry at the Freie Universität Berlin
  • 10/2001-06/2002: academic degree „Diplom-Biochemiker“
  • 07/2002-05/2008: PhD post-graduation at the Deutschen Rheuma-Forschungszentrum, Working Group Dr. A. Thiel

Professional experience

  • 06/2008-06/2009: Post-Doc Position at the Deutsches Rheuma-Forschungszentrum
  • 07/2009- Post-Doc Position at the Berlin-Brandenburg School of Regenerative Therapies

Publications

  • Meier S, Stark R, Frentsch M, Thiel A. The influence of different stimulation conditions on the assessment of antigen-induced CD154 expression on CD4+ T cells. Cytometry A. 2008 Nov;73(11):1035-42.
  • Kirchhoff D, Frentsch M, Leclerk P, Buman D, Rausch S, Hartmann S, Thiel A, Scheffold A. Identification and isolation of murine antigen-reactive T cells according to CD154 expression. Eur J Immunol. 2007 Sep; 37(9):2370-7.
  • Frentsch M, Arbach O, Kirchhoff D, Moewes B, Worm M, Rothe M, Scheffold A, Thiel A. Direct access to CD4+ T cells specific for defined antigens according to CD154 expression. Nat Med. 2005 Oct; 11(10):1118-24
  • Meissner F, Maruyama T, Frentsch M, Hessell AJ, Rodriguez LL, Geisbert TW, Jahrling PB, Burton DR, Parren PW. Detection of antibodies against the four subtypes of ebola virus in sera from any species using a novel antibody-phage indicator assay. Virology. 2002 Sep 1; 300(2):236-43.
  • Schoenbrunn A, Kohler S, Frentsch M, Dooms H, Moewes B, Loddenkemper C, Romagnani C, Thiel A 4-1BB, a marker to identify and isolate antigen-specific CD4+CD25+ Foxp3+ regulatory T cells. In review

Research Interest

The development of potent vaccines that are able to induce protective humoral and cellular immune responses are of high interest in public health care, particularly to overcome vaccination unresponsiveness in the elderly. This project aims to enhance vaccination efficiency by co-encapsulation of intracellular pathogen receptor ligands with antigens in microspheres (MS). MS are taken up efficiently by professional antigen presenting cells (APC) where they release their encapsulated components with predefined kinetics. The focus of this project is i) the analysis of immunological effects of the MS encapsulated with various intracellular receptor ligands on different APC populations in vitro and in vivo in experimental models, ii) the modulation of immune responses after MS immunization with different formulated MS and intracellular receptor ligands, and iii) the examination of the potential of such MS to induce protective and long-lasting adaptive immune responses in infection models.

Dr. Nadine Matzmohr

Contact

Phone: +49 (0)30 - 450 539 457/ 458
Fax: +49 (0)30 - 450 539 955
nadine.matzmohr[at]charite.de

 

 

 

Academic education

2000-2006                   Studied Veterinary Medicine at the Freie Universität Berlin

2007-2010                   PhD student at the Deutsches Rheuma- Forschungszentrum

                                    Berlin

                                    Working group of Dr. Alexander Scheffold

Since May 2011           Post Doc position at the Berlin Brandenburg Center for

                                    Regenerative Therapies (BCRT)

                                    Working group of Prof. Dr. Andreas Thiel

Publications

1. Kassner N, Krueger M, Yagita H, Dzionek A, Hutloff A, Kroczek R, Scheffold A, Rutz S. Cutting edge: Plasmacytoid dendritic cells induce IL-10 production in T cells via the Delta-like-4/Notch axis. J Immunol. 2010 Jan 15;184(2):550-4.2.  

2. Rutz S, Janke M, Kassner N, Hohnstein T, Krueger M, Scheffold A. Notch regulates IL-10 production by T helper 1 cells. Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3497-502

 

Ulrik Stervbo-Kristensen

Contact

Phone +49 30 450-539535

Fax +49 30 450-539955

Ulrik.Stervbo-Kristensen[at]charite.de

 

 

Academic Education

  • 2005: Master of science – Degree at the Roskilde University, Roskilde Denmark
  • 2006: Research Assistant at the MDC Berlin, Clinical Cardiology and Molecular Oncology Groups
  • 2007- 07/2011: PhD at the DRFZ, Berlin in the working Group of Dr. Simon Fillatreau, Thesis title: Antigen recognition properties of regulatory and conventional CD4+ T cells key achievements.
  • Since 08/2011: Post Doc in the Groups Prof. Andreas Thiel and Prof. Avidan Neumann at the BCRT, Berlin, Germany

PhD Students/Graduate Students

Julian Braun

Contact:

Phone: +49 (0)30 - 450 539 457
julian.braun[at]charite.de

 

Academic education

2002-2007           Student of biology at the Eberhard-

                            Karls-University in Tübingen, Germany

2007-2008           Diploma thesis at the Zentrum für Regenerationsbiologie und

                            regenerative Medizin, ZRM, Tübingen

                            Working group of Prof. Dr. Wilhelm K. Aicher, University Clinic Tübingen,

                            UKT, Germany

Since 09/2008     PhD thesis at the Berlin-Brandenburg Center for Regenerative

                            Therapies (BCRT)

                            Working group of Prof. Dr. Andreas Thiel

                            Project title: Epigenetic signature of human mesenchymal stem cells

Sibel Durlanik

Contact

Phone: +49 (0)30 - 450 539 458
sibel.durlanik[at]charite.de

 

Academic education

09/2002-06/2007        B.Sc in Molecular Biology and

                                    Genetics, Middle East Technical

                                    University, Ankara, Turkey

10/2007-07/2009        M.Sc in Molecular Bioscience – Infectious Disease Major

                                    Ruprecht-Karls University Heidelberg, Germany

                                    Thesis title: Analysis of CD32-independent stimulation of

                                    plasmacytoid dendritic celly by S. aureus

Since 10/2009             PhD student at the Berlin Brandenburg Center for Regenerative

                                    Therapies (BCRT)

                                    Working group of Prof. Dr. Andreas Thiel

                                    Project title: Characterisation of helper functions exerted by

                                    CD154+CD8+ T cells

Annett Ullm

Contact

Phone: +49 (0)30 - 450 539 457
annett.ullm@charite.de

 

Academic education

10/2002-06/2008        Diploma Engineer for medical

                                    biotechnology

01/2007-09/2007        Diplomathesis in the Department for Cancer Research and

                                    Immunology, Oklahoma Medical Research Foundation (OMRF)

                                    Working group of Dr. Thompson, Oklahoma City, USA

                                    Thesis title: Human thymocyte αß vs. γδ lineage decision

07/2009-09/2010        research at the Berlin Brandenburg Center for Regenerative

                                    Therapies (BCRT)

                                    Working group of Prof. Dr. Andreas Thiel

Since 10/2010             PhD thesis at the Berlin Brandenburg Center for Regenerative

                                    Therapies (BCRT)

                                    Working group of Prof. Dr. Andreas Thiel

                                    Project title: In vitro generation of human T lymphocytes-from fetal

                                    thymic organ cultures (FTOC) to defined 3D culture systems

Jacqueline Keye

Contact

Phone: +49 (0)30 - 450 539 457
jacqueline.keye[at]charite.de

 

Academic education

Since 2005                 studies at the E.-M.-A. University of

                                   Greifswald, Germany

August 2010              Diploma thesis thesis at the Berlin Brandenburg Center for

                                   Regenerative Therapies (BCRT)

                                   Working group of Prof. Dr. Andreas Thiel

Since October 2010   PhD thesis at the Berlin Brandenburg Center for Regenerative

                                  Therapies (BCRT)

                                   Working group of Prof. Dr. Andreas Thiel

                                   Project title: Parallele Analyse und Isolierung Antigen-spezifischer

                                   regulatorischer und konventioneller T Zellen"

Sarah Meier

Contact

Phone: +49 (0)30 - 450 539 457
sarah.meier[at]charite.de

 

Academic education

1999-2005                     Studies in Biology at the University

                                      of Konstanz, Germany

2005                              Diploma thesis at the Department of Biochemical Pharmacology,

                                      University of Konstanz, Germany

                                      Working group of Prof. Dr. T Hartung

2006                              Research Assistant at GenPat77 Pharmacogenetics AG in

                                      cooperation with Charité Berlin, Institute of Medical Immunology,

                                      Germany

Since 2007                     PhD student at the Deutsches Rheuma-Forschungszentrum

                                      (DRFZ), Berlin and Humboldt University, Berlin

                                      Working group of Prof. Dr. Andreas Thiel (Department of Clinical

                                      Immunology)

Since February 2009    PhD thesis at the Berlin Brandenburg Center for Regenerative

                                      Therapies (BCRT)

                                      Working group of Prof. Dr. Andreas Thiel

Regina Stark

Contact

Phone: +49 (0)30 - 450 539 457
regina.stark[at]charite.de

 

Academic education

10/2002-04/2008        studies of Biochemistry at the

                                    University Potsdam

Since 05/2008             PhD student in the International Max Planck Research School for

                                    Infectious Diseases and Immunology (IMPRS-IDI)

                                    Working group of Prof. Dr. Andreas Thiel in the Berlin Brandenburg

                                    Center for Regenerative Therapies (BCRT), Berlin, Germany

                                    Project title: Differentiation of CD8+ Helper T cells

Anne Schönbrunn

Contact

Phone: +49 (0)30 - 450 539 457
anne.schoenbrunn[at]charite.de

 

Academic education

2000-2006              studies in Biology at the Humboldt-

                               University Berlin, Germany

                               Diploma thesis at the Deutsches Rheuma-Forschungsinstitut

                               (DRFZ), Germany

                               Topic: Identification of antigen-reactive regulatory T cells using a

                               specific activation-marker signature

                               Working group of Dr. Andreas Thiel (Clinical Immunology)

12/2006-02/2007   research assistant in the Clinical Immunology group at the DRFZ

Since 02/2007        PhD thesis at the DRZF and at the Berlin Brandenburg Center for

                               Regenerative Therapies (BCRT), Berlin, Germany

Axel Schulz

Contact

Phone: +49 (0)30 - 450 539 458
a.schulz[at]charite.de

 

Academic education

2002-2006           Bachelor´s program “Molecular

                            Bioengineering” at Dresden University of

                            Technology

                            Thesis at the Robert-Koch-Institut in Berlin, Germany

                            Thesis title: Expression analysis of structural proteins from the human

                            coronavirus NL63 (HCoV-NL63) in pro- and eukaryotes

2006-2009           Master´s program “Molecular Medicine”, Charité-Berlin

                            Thesis at the Deutsches Rheuma-Forschungsinsitut (DRFZ), Berlin in

                            the group of   Prof. Dr. Andreas Thiel (Clinical Immunology)

                            Thesis title: 'Approaching the Cellular Immune Response against Viruses

                            with a Novel RNA Transfection Based Assay'

Since 2009          PhD thesis at the Berlin Brandenburg Center for Regenerative

                            Therapies (BCRT), Berlin, Germany

                            Working group of Prof. Dr. Andreas Thiel

                            Project title: CD8 CD40L T-cells and the human T-cell repertoire in the

                            context of Yellow Fever Vaccination

Alberto Sada Japp

Contact

Phone: +49 (0)30 - 450 539 457
Fax: +49 (0)30 - 450 539 955
alberto.japp[at]charite.de

 

Academic education

2003-2009           Studies Pharmacy and Clinical

                            Laboratory Medicine at the Federal University of Rio de Janeiro (UFRJ),

                            Brazil

Since 2009          Master Student of Molecular Medicine at the Charité Universitätsmedizin

                            Berlin

                            Master thesis at the Berlin Brandenburg Center for Regenerative

                            Therapies (BCRT)

                            Working group of Prof. Dr. Andreas Thiel

Since November 2011   PhD Student, Thesis concerning: The role of CD40L expressing CD8+                                     helper T cells in tumor rejection.

 

Hanne Schaffert

Contact

hanne.schaffert[at]charite.de

 

Academic education

2003 - 2007              Study of biology at the University of

                                 Konstanz, Germany

2007- 2008               Diploma student at the University of

                                 Konstanz

                                 diploma thesis: Detection of Chlamydophila pneumoniae specific

                                 T-cells by flow cytometric analysis” at the department of

                                 Biochemical Pharmacology

since 2009                Ph.D. student at the Charité Berlin,

                                 doctoral thesis: Immunopathogenesis of Myasthenia gravis

 

Technical assistant

Beate Möwes

Contact

Phone: +49 (0)30 - 450 539 498 or 457
beate.moewes[at]charite.de

 

Academic education

1996-1998   Education as technical assistant,

                    Oberstufenzentrum Potsdam Mittelmark,

                    Germany

1999-2008   Technical assistant at the German Arthritis Research Centre in the Clinical

                     Immunology Group, DRFZ Berlin, Germany

Since 2009   Technical assistant at the BCRT in the Group Prof. Dr. Thiel (Regenerative

                     Immunology and Aging)

Karolina Grzeschik

Contact

Phone: +49 (0)30 - 450 539 457
karolina.grzeschik[at]charite.de

 

Academic education

2002 -02/2006       Landwirtschaftsakademie in Breslau

                              (Polen) Fachbereich:

                              Nahrungsmittelwissenschaft

                              Studiengang: Biotechnologie, Vertiefungsrichtung:

                              Nahrungsmittelbiotechnologie

                              Abschluss: Berufstitel Ingenieurin (anerkannt als Bachelor)

04/2007 -06/2009  Beuth Hochschule für Technik Berlin, Fachbereich: V, Life Science

                              and Technology, Studiengang: Biotechnologie Master (M.Sc.)

Seit 11/2009          Tech. Assistentin, AG Thiel, BCRT, Charité-Universitätsmedizin Berlin

Manuela Krüger

Contact

Phone: +49 (0)30 - 450 539 457
Fax: +49 (0)30 - 450 539 955
manuela.krueger[at]charite.de

 

Academic education

1998-2003            Studies Biotechnology at the Technical University in Berlin

2003-01/2009       Technical assistant at the German Arthritis Research Centre in the

                             Clinical Immunology Group, DRFZ Berlin, Germany

02/2009-08/2009  Technical assistant at the Charité- Universitätsmedizin Berlin in the

                              Group of Prof. Alf Hamann

Since 10/2010       Technical assistant at the Charité- Universitätsmedizin Berlin in the

                              Group of Prof. Andreas Thiel

Antje Maluck

Contact

Phone +49 (0)30 450 539 535

Fax +49 (0)30 450 539 955

antje.maluck[at]charite.de

Academic education

  • 1996-1998: Education as trader at the EP Fenske; Brandeburg/ Havel
  • 2007-2010: Education as Biological Technical Assistant at the Lise-Meitner-Schule, 12351 Berlin
  • Since January 2012: Technical Assistant in the working Group of Prof. Andreas Thiel at the BCRT, Berlin, Germany

Diploma/Master students/Undergraduate students

Dimas Abdirama, Biology Student

Contact

Phone: +49 (0)30 - 450 539 457/458
Fax: +49 (0)30 - 450 539 955
dimas.abdirama[at]charite.de

 

Academic education

2005-2011           Medical Biotechnology Student at Berlin

                            Institute of Technology (TU Berlin)
Since 2011          Diploma Thesis Berlin-Brandenburg Center for Regenerative Therapies

                            (BCRT)

                            Working group of Prof. Dr. Andreas Thiel

                            Project title: Characterization of Pluripotency Transcription Factors in

                            Different Human Tissues and Transcription Factor Expression in

                            Human Stem Cells assessed by Flow Cytometry

Anett Haese, Biology Student

Contact

Phone: +49 (0)30 - 450 539 457/458
Fax: +49 (0)30 - 450 539 955
anett.haese@charite.de

 

Academic education

  • Since 2004: Biotechnology Student  in the Westfälische Wilhelms-Universitäts Münster
  • Since February 2011: laboratory assistant in the group of Prof. Andreas Thiel at the BCRT, Berlin, Germany
  • March 2012: Graduation in Master of Science M.Sc., course of studies: Bioscience
  • Since May 2012: PhD Student

Medical students

Julia Nora Mälzer, MD Student

Contact

Phone: +49 (0)30 - 450 539 457
julia-nora.maelzer[at]charite.de

 

Academic education

since 10/2007            medical student at the Charité-

                                   Universitätsmedizin Berlin

since 10/2010            MD thesis at the Berlin Brandenburg Center for Regenerative

                                   Therapies (BCRT)

                                   working group of Prof. Dr. A. Thiel

                                   Thesis title: Quality and Kinetics of the Immuneresponse

                                   against Yellow Fever in elderly Vaccinees

Julian Marcel Waldner

Contact

Phone +49 (0)30 450 539 528/457

Fax +49 (0)30 450 539 955

julian.waldner[at]charite.de

 

Academic Education

  • Since April 2007: Medical Student at the Charité-Universitätsmedizin Berlin
  • Since August 2011: at the Charité- Universitätsmedizin Berlin in the Group of Prof. Andreas Thiel at the BCRT, involved in the PRIMAGE Study

Administrative staff

Maria Santoro, Administrative Assistant

Secretary to Prof. Andreas Thiel
Regenerative Immunology and Aging
Berlin-Brandenburg Center for Regenerative Therapies (BCRT)
Charité - Universitätsmedizin Berlin
Campus Virchow-Klinikum
Augustenburger Platz 1 (Südstraße 2)
13353 Berlin
Germany

Phone: +49 30 450 539 502
FAX: +49 30 450 539 955
maria.santoro[at]charite.de

 

Academic education

1999-2005        studies foreign-philology at the University in Rom, Italy

2005-2009        Secretary to Prof. Thomas Unger, Director, Center for Cardiovascular

                         Research (CCR) and Institute for Pharmacology, Charité -

                         Universitätsmedizin Berlin

Since 09/2009  Secretary to Prof. Andreas Thiel, BCRT Berlin Brandenburg Center for

                         Regenerative Therapies, Charité - Universitätsmedizin Berlin

Dr. Susanne Eiglmeier, Administrative staff

Contact

Phone: +49 (0)30 - 450 539 498
Fax: +49 (0)30 - 450 539 955
susanne.eiglmeier[at]charite.de

 

Academic education

10/2002-12/2006         University of Kassel, Germany

                                    studying biology

10/2004-05/2005         University of Siena, Italy studying biology

10/2006-06/2007         Max-Delbrück-Centrum for Molecular Medicin, Berlin

                                     Diploma thesis in the research group of Prof. Dr. A. Leutz

                                     Thesis title: The transcription factor IRF-8 as a new target gene

                                     of the Wnt/beta-catenin signaling pathway in hematopiesis

01/2008-01/2011          German Rheumatoid Research Center, Berlin

                                     PhD Thesis in the research group of Dr. Marc Ehlers

                                     Thesis: Role of Th17 cells and sialylated antigen-specific

                                     antibodies in rheumatic autoimmune diseases.

Since 02/2011              coordinator for PR and fundraising at the Berlin Brandenburg

                                     Center for Regenerative Therapies (BCRT) in the group of

                                     Prof. Dr. Andreas Thiel

Core facility

Dr. Désirée Kunkel, Head of 'BCRT Flow Cytometry Lab'

Head of BCRT Flow Cytometry Lab

Berlin-Brandenburg Center for Regenerative Therapies (BCRT)
Charité - Universitätsmedizin Berlin
Campus Virchow-Klinikum
Augustenburger Platz 1
D-13353 Berlin

Phone: + 49 30 450 539 446
Fax: + 49 30 450 539 902
desiree.kunkel[at]charite.de

 

Academic education

1997-1998        Diploma thesis (Biologie), group of Andreas Radbruch, Institute for

                         Genetics of the University of Cologne and German Rheumatism

                         Research Center (DRFZ), Berlin, Germany

1998-2002        PhD student (Biology/Immunology), group of Alexander Scheffold,

                         German Rheumatism Research Center (DRFZ) and Humboldt University,

                         Berlin, Germany

2002-2006        Postdoc, group of Thomas Schneider, Department of Infectious Diseases,

                         Medical Clinic I, Charité CBF, Berlin, Germany

2006-2008        Postdoc (Fellowship from SIDACTION and ANRS), group of Michaela

                          Müller-Trutwin, Unit 'Régulation des Infections Rétrovirales',

                          Department of Virology, Institut Pasteur, Paris, France

since 08/2008   Head of BCRT Flow Cytometry Lab, Berlin-Brandenburg Center for

                          Regenerative Therapies (BCRT), Berlin, Germany

Selected publications

  1. Jacquelin B, Mayau V, Targat B, Liovat AS, Kunkel D, Petitjean G, Dillies MA, Roques P, Butor C, Silvestri G, Giavedoni LD, Lebon P, Barré-Sinoussi F, Benecke A, Müller-Trutwin MC. Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly controlled type I IFN response. J Clin Invest. 2009 Dec;119(12):3544-55.
  2. Reversade B, Escande-Beillard N, Dimopoulou A, Fischer B, Chng SC, Li Y, Shboul M, Tham PY, Kayserili H, Al-Gazali L, Shahwan M, Brancati F, Lee H, O'Connor BD, Schmidt-von Kegler M, Merriman B, Nelson SF, Masri A, Alkazaleh F, Guerra D, Ferrari P, Nanda A, Rajab A, Markie D, Gray M, Nelson J, Grix A, Sommer A, Savarirayan R, Janecke AR, Steichen E, Sillence D, Hausser I, Budde B, Nürnberg G, Nürnberg P, Seemann P, Kunkel D, Zambruno G, Dallapiccola B, Schuelke M, Robertson S, Hamamy H, Wollnik B, Van Maldergem L, Mundlos S, Kornak U. Mutations in PYCR1 cause cutis laxa with progeroid features. Nat Genet. 2009 Sep;41(9):1016-21
  3. Moos V, Schmidt C, Geelhaar A, Kunkel D, Allers K, Schinnerling K, Loddenkemper C, Fenollar F, Moter A, Raoult D, Ignatius R, Schneider T. Impaired Immune Functions of Monocytes and Macrophages in Whipple's Disease. Gastroenterology. 2009 Aug 5.
  4. Epple HJ, Schneider T, Troeger H, Kunkel D, Allers K, Moos V, Amasheh M, Loddenkemper C, Fromm M, Zeitz M, Schulzke JD. Impairment of the intestinal barrier is evident in untreated but absent in suppressively treated HIV-infected patients. Gut. 2009 Feb;58(2):220-7.
  5. Diop OM, Ploquin MJ, Mortara L, Faye A, Jacquelin B, Kunkel D, Lebon P, Butor C, Hosmalin A, Barré-Sinoussi F, Müller-Trutwin MC. Plasmacytoid dendritic cell dynamics and alpha interferon production during Simian immunodeficiency virus infection with a nonpathogenic outcome. J Virol. 2008 Jun;82(11):5145-52.
  6. Allers K, Kunkel D, Moos V, Eisenblätter M, Stahl-Hennig C, Kaup FJ, Ignatius R, Schneider T. Migration patterns of nonspecifically activated versus nonactivated nonhuman primate T lymphocytes: preferential homing of activated autologous CD8+ T cells in the rectal mucosa. J Immunother. 2008 May;31(4):334-44.
  7. Epple HJ, Loddenkemper C, Kunkel D, Tröger H, Maul J, Moos V, Berg E, Ullrich R, Schulzke JD, Stein H, Duchmann R, Zeitz M, Schneider T. Mucosal but not peripheral FOXP3+ regulatory T cells are highly increased in untreated HIV infection and normalize after suppressive HAART. Blood. 2006 Nov 1;108(9):3072-8.
  8. Moos V, Kunkel D, Marth T, Feurle GE, LaScola B, Ignatius R, Zeitz M, Schneider T. Reduced peripheral and mucosal Tropheryma whipplei-specific Th1 response in patients with Whipple's disease. J Immunol. 2006 Aug 1;177(3):2015-22.
  9. Kunkel D, Kirchhoff D, Volkmer-Engert R, Radbruch A, Scheffold A. Sensitive visualization of peptide presentation in vitro and ex vivo. Cytometry A. 2003 Jul;54(1):19-26.
  10. Kunkel D, Kirchhoff D, Nishikawa S, Radbruch A, Scheffold A. Visualization of peptide presentation following oral application of antigen in normal and Peyer's patches-deficient mice. Eur J Immunol. 2003 May;33(5):1292-301.
  11. Wang YH, Stephan RP, Scheffold A, Kunkel D, Karasuyama H, Radbruch A, Cooper MD. Differential surrogate light chain expression governs B-cell differentiation. Blood. 2002 Apr 1;99(7):2459-67.
  12. Polic B, Kunkel D, Scheffold A, Rajewsky K. How alpha beta T cells deal with induced TCR alpha ablation. Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8744-9.

Former employees

Dr. Jun Dong

Contact:

Phone: +49 (0)30 - 450 539 489
jun.dong[at]charite.de

Research interests

My research of interests include T cell subsets as well as mesenchymal stem cell (MSC) differentiation. My research is to understand the epigenetic mechanisms that underlie signature gene regulation of immune cells and MSC self-renewal and plasticity. Emphasis is given to the epigenetic regulation by DNA methylation.

BCRT project

In a joint project in collaboration with Prof. Dr. S. Mundlos and PD Dr. A. Kurtz at the BCRT, we are dedicated to use a highly competitive research program dealing with cellular and molecular approaches, such as bioinformatics and genome data analysis, flow cytometry, next generation sequencing and in vitro functional assay, to assess and validate DNA methylation patterns of genes of interest in certain stage of clinical-grade MSCs. The goal of our research is to understand epigenetic regulation of MSCs and to identify epigenetic markers unique to (tissue-specific) MSCs in order to lay the basis for MSC-based clinical studies with potential therapeutic benefits.

Cecilia Bozzetti

Contact

Phone +49 (0)30 450 539 528/ 457

Fax +49 (0)30 450 539 955

cecilia.bozzetti[at]charite.de

 

Academic education

 

2002-2005: Bachelor Degree in Languages and Science Communication at the Sacro Cuore University, Milan Italy

Since 2007: Medical Student at the Charité-Universitätsmedizin Berlin

Since August 2011 Position at DRFZ as medical student assistant, involved in the PRIMAGE Study

Dominika Rachwalik

Contact

Phone +49 (0)30 450 539 528/ 457

Fax +49 (0)30 450 539 955

dominika.rachwalik[at]charite.de

 

Academic education

 

Since October 2007: Medical Student at the Charité-Universitätsmedizin Berlin

Since August 2011 Position at DRFZ as medical student assistant, involved in the PRIMAGE Study

Lisa Grohmann

Contact

Phone: +49 (0)30 - 450 539 457
Fax: +49 (0)30 - 450 539 955

lisa.grohmann[at]charite.de

Academic education

since 10/2006   study in biochemistry at Freie Universität

                          Berlin (grade: diploma)

since 12/2010   Diploma thesis at the Berlin Brandenburg Center for Regenerative

                          Therapies (BCRT)

                          working group of Prof. Dr. Andreas Thiel

                          topic: haptenylation of antibodies for immunohistochemistry

Anna Okhrimenko, Trainee

Contact

Phone: +49 (0)30 - 450 539 457
Fax: +49 (0)30 - 450 539 955
anna.okhrimenko@charite.de

 

Academic education

10/2006 -07/2009     Philipps-Universität Marburg; Grade:

                                  B.Sc. Biology

since 10/2009           Charité University Medical School, Berlin; Master’s Program in

                                  Molecular Medicine

since 02/2011            Master’s thesis at the Berlin Brandenburg Center for Regenerative

                                  Therapies (BCRT)

                                  Working group of of Prof. Dr. Andreas Thiel

                                  Topic: Epigenetic regulation of the IFNG gene in human IFNg
                                  producing memory T lymphocytes

Friedemann Jobst, MD thesis

Contact

Phone: +49 (0)30 - 450 539 457
friedemann.jobst[at]charite.de

 

Academic education

2005 – 2007         medical student at the Julius-Maximilians-

                             Universität, Würzburg

2007 – 2009         medical student at Charité – Universitätsmedizin Berlin

2008 – 2009         exchange semester at the University of Tromso, Norway

Since 08/2009      MD thesis at the Berlin Brandenburg Center for Regenerativ

                             Therapies (BCRT)

                             working group of Prof. Dr. A. Thiel

                             Thesis title: Epigenetic and molecular regulation of costimulatory

                             molecule expression in human regulatory T cells and their effector

                             T cell counterparts

Anne Herholz, MD student

Contact


anne.herholz[at]charite.de

Academic education

2009                   Graduation in Medicine, Universitätsmedizin

                           Charité Berlin

Since July 2009  MD Student, BCRT – Berlin Brandenburg Center

                           of  Regenerative Therapies, Immune Regeneration and Aging, Prof. Dr.

                           Andreas Thiel

Sabine Stark, Trainee

Contact


sabine.stark[at]charite.de

Friedrich Wittenbecher, Student

Contact


friedrich.wittenbecher[at]charite.de

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